NURUL IZZAH BINTI SHARI, NURUL IZZAH (2020) EFFECT OF BRIEF ACCEPTANCE AND COMMITMENT THERAPY (ACT) ON SUBJECTIVE COGNITIVE IMPAIRMENT IN NON-METASTATIC BREAST CANCER PATIENTS UNDER CHEMOTHERAPY. Doctoral thesis, UNIVERSITI MALAYA.
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EFFECT OF BRIEF ACCEPTANCE AND COMMITMENT THERAPY (ACT) ON SUBJECTIVE COGNITIVE IMPAIRMENT IN NON-METASTATIC BREAST CANCER PATIENTS UNDERGOING CHEMOTHERAP.pdf - Submitted Version Restricted to Registered users only Download (28MB) | Request a copy |
Abstract
Introduction: Subjective cognitive impairment is commonly reported by breast cancer patients undergoing chemotherapy but the understanding about its management is limited. This study examined the efficacy of a four-session acceptance and commitment therapy (ACT) on subjective cognitive impairment in non-metastatic breast cancer patients undergoing chemotherapy. This study also aimed to examine the predictors of subjective cognitive impairment and the mediation effect of psychological inflexibility and post-traumatic growth on the relationship between anxiety, depression and fatigue with subjective cognitive impairment. Methods: Data collections were done before adjuvant chemotherapy for baseline data, during chemotherapy sessions (cycle 4) for screening and one month after completed chemotherapy for post-treatment. Respondents who had a reduction in FACT-Cog scores between 6.9- to 10.6 from baseline scores were recruited into the randomized controlled trial (RCT) study which consists of two arms: ACT (30 cases) and waitlist (30 control) groups. Results: From 180 respondents at baseline, only 60 respondents reported to have significant subjective cognitive impairment during screening. Cases in the ACT group showed significant improvement in subjective cognitive impairment, post-traumatic growth and reduction in depression, anxiety and psychological inflexibility after the ACT intervention. All outcomes except for fatigue in the waitlist group have no significant changes over time. After controlling the covariates, group differences in all variables were significant except for fatigue. About 56.8% of the variation in subjective cognitive impairment was explained by anxiety, depression, psychological inflexibility and fatigue. Relationships between anxiety and fatigue with subjective cognitive impairment were partially mediated by psychological inflexibility. Conclusion: ACT might be considered as an effective intervention to ameliorate subjective cognitive impairment, anxiety, depression, psychological inflexibility and improve post-traumatic growth in cancer patients on chemotherapy. This study also provides evidence on the efficacy and feasibility of brief ACT intervention in overcoming subjective cognitive impairment.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universiti > Universiti Malaya (UM) |
| Depositing User: | Encik Mohd Zulkarnain Hassan bin Mohd Zainudin |
| Date Deposited: | 04 Oct 2024 11:35 |
| Last Modified: | 04 Oct 2024 11:35 |
| URI: | https://repositori.mohe.gov.my/id/eprint/12 |
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