Ahmad Faizal Bin Roslan, Ahmad Faizal (2020) Scanning Electron Microscopy Study Of Novel Biomaterial Antibiotic Delivery System For Treatment Of Osteomyelitis In New Zealand White Rabbit (Nzwr) Model. Masters thesis, UNIVERSITI ISLAM ANTARABANGSA MALAYSIA.
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Scanning Electron Microscopy Study Of Novel Biomaterial Antibiotic Delivery System For Treatment Of Osteomyelitis In New Zealand White Rabbit (Nzwr) Model.pdf Restricted to Registered users only Download (2MB) |
Abstract
Treatment of osteomyelitis is still evolving in orthopaedics. The aim of this study is to evaluate the treatment of osteomyelitis using Gentamicin impregnated biomaterials in New Zealand White Rabbit (NZWR) model. Osteomyelitis was created by inoculation of Staphylococcus aureus ATCC 25923 into the drilled distal femur of NZWR. Thirty-four (34) NZWR were used during the study. They were divided into two groups Hydroxyapatite (HA) vs Calcium sulphate, (CaSO4) ) with four subgroups at weeks 3, 6, 12 and 26. The response of the treatment with Gentamicin impregnated biomaterials Hydroxyapatite (HA) and Calcium sulphate (CaSO4) against the infection were evaluated through Scanning Electron Microscope (SEM). The rabbits were sacrificed at intervals to evaluate the healing process of the affected bone. The results showed osteomyelitis changes of the rabbit at 3,6,12 and 26 weeks. SEM findings showed the presence of CaSO4 biomaterial at 3, 6 weeks and absent at 12 and 26 weeks. HA is present until 26 weeks. Biofilm is visible under SEM in HA group at 12 and 26 week. At week 26, features of marked osteolysis activity suggesting recurrence in the CaSO4 group. At week 26, there are fewer osteomyelitis changes and more remodelling of the bone in the HA group as compared to CaSO4 group. Gentamicin impregnated HA showed good osseointegration, biocompatibility and slower dissolution compared to Gentamicin impregnated CaSO4. In conclusion, these findings suggest that Hydroxyapatite shows significant potential as a drug delivery system in the treatment of osteomyelitis due to its slower dissolution. This study also highlights the importance of longer duration of assessment in experimental osteomyelitis due to potential of recurrence.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Universiti > Universiti Islam Antarabangsa Malaysia (IIUM) |
| Depositing User: | Encik Mohd Zulkarnain Hassan bin Mohd Zainudin |
| Date Deposited: | 04 Sep 2025 14:19 |
| Last Modified: | 04 Sep 2025 14:19 |
| URI: | https://repositori.mohe.gov.my/id/eprint/121 |
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